Why Valproate is used in Migraine Prophylaxis / Treatment ?

A) Valproate increases brain GABA levels and, in doing so, may suppress migraine-related events in the cortex, perivascular parasympathetics or trigeminal nucleus caudalis. 

There is experimental evidence that it suppresses neurogenic inflammation and directly attenuates nociceptive (pain stimuli) neurotransmission.

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